What is the typical IV bolus dose of ephedrine?

What is the typical IV bolus dose of ephedrine?

• A. 1-2 mg
• B. 5-10 mg
• C. 15-20 mg
• D. 25-30 mg

Answer: (B)

Ephedrine works by increasing sympathetic activity both directly (alpha and beta stimulation) and indirectly by promoting release of endogenous norepinephrine. This dual action raises blood pressure quickly, making it useful for treating intraoperative hypotension. Because the goal is to restore perfusion promptly while avoiding excessive tachycardia or hypertension, a modest IV bolus is used. The typical amount is 5 to 10 mg, given IV, with the possibility of repeating every few minutes if needed. Doses in the 15–20 mg range or higher carry a higher risk of adverse effects and are not preferred as first-line boluses. Very small doses like 1–2 mg are often insufficient to raise blood pressure effectively in the operative setting. Therefore, 5–10 mg is the standard, best-fit range for an initial ephedrine bolus.

Ephedrine works by increasing sympathetic activity both directly (alpha and beta stimulation) and indirectly by promoting release of endogenous norepinephrine. This dual action raises blood pressure quickly, making it useful for treating intraoperative hypotension. Because the goal is to restore perfusion promptly while avoiding excessive tachycardia or hypertension, a modest IV bolus is used. The typical amount is 5 to 10 mg, given IV, with the possibility of repeating every few minutes if needed. Doses in the 15–20 mg range or higher carry a higher risk of adverse effects and are not preferred as first-line boluses. Very small doses like 1–2 mg are often insufficient to raise blood pressure effectively in the operative setting. Therefore, 5–10 mg is the standard, best-fit range for an initial ephedrine bolus.