What is the primary effect of alpha-1 agonism?

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Multiple Choice

What is the primary effect of alpha-1 agonism?

Explanation:
Activation of alpha-1 receptors on vascular smooth muscle causes contraction, leading to vasoconstriction. This constricts blood vessels, increases systemic vascular resistance, and raises blood pressure. The higher pressure can trigger a reflex slowing of the heart, but the direct, primary effect of alpha-1 agonism is narrowing of vessels, not a decrease in heart rate. Bronchodilation is mediated by beta-2 receptors in the airways, and a direct decrease in heart rate is not the primary action of alpha-1 stimulation. So the main effect is vasoconstriction.

Activation of alpha-1 receptors on vascular smooth muscle causes contraction, leading to vasoconstriction. This constricts blood vessels, increases systemic vascular resistance, and raises blood pressure. The higher pressure can trigger a reflex slowing of the heart, but the direct, primary effect of alpha-1 agonism is narrowing of vessels, not a decrease in heart rate. Bronchodilation is mediated by beta-2 receptors in the airways, and a direct decrease in heart rate is not the primary action of alpha-1 stimulation. So the main effect is vasoconstriction.

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